Mehdi Rajabi, Ph.D.


  • Ph.D. Molecular Medicine, 2010, Milan State University, Milan, Italy
  • M.S. Organic Chemistry, 2007, Azad University, Tehran, Iran


  • As a bioconjugate chemist, I study the chemical modification of different small bioactive molecules for conjugation to nanoparticles for cancer delivery applications. A significant part of my research plan is devoted to development of novel nano-structures for application in nanomedicine.
Selected Publications
  1. Shohreh Nafisi, Mehrdad Hashemi, Mehdi Rajabi, Heidar-Ali Tajmir-Riahi. DNA adducts with antioxidant flavonoids: morin, apigenin, and naringin. DNA and Cell Biology. 27, 2008, 433-42.
  2. Charalabos D. Kanakis, Shohreh Nafisi, Mehdi Rajabi, Azadeh Shadaloi, Petros A. Tarantilis, Moschos G. Polissiou, Joseph Bariyanga, Heidar-Ali Tajmir-Riahi. Structural analysis of DNA and RNA, interactions with antioxidant flavonoids. Spectroscopy. 23, 2009, 29-48.
  3. Gioseppe Meroni, Mehdi Rajabi, Enzo Santaniello. D-Luciferin, derivatives and analogues: synthesis and in vitro / in vivo luciferase-catalyzed bioluminescent activity. ARKIVOC. (i), 2009, 265-288.
  4. Gioseppe Meroni, Mehdi Rajabi, Paolo Ciana, Adriana Maggi, Enzo Santaniello. Synthesis of 2-cyano-6-methoxy benzothiazole, a key intermediate for the synthesis of firefly luciferin, starting from 1,4-benzoquinone. ARKIVOC. (vi), 2010, 53-60.
  5. Simone Bertini, Vincenzo Calderone, Isabella Carboni, Roberta Maffei, Alma Martelli, Adriano Martinelli, Filippo Minutolo, Mehdi Rajabi, Lara Testai, Tiziano Tuccinardi, Riccardo Ghidoni, Marco Macchia. Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties. Bioorganic & Medicinal Chemistry. 18, 2010, 6715–6724.
  6. Mehdi Rajabi, Paola Signorelli, Elena Gorincioi, Riccardo Ghidoni, Enzo Santaniello. Antiproliferative activity of N6-isopentenyladenosine on MCF-7 breast cancer cells: cell cycle analysis and DNA-binding study. DNA and Cell Biology. 29, 2010, 687-691.
  7. Alberto Milanese, Elena Gorincioi, Mehdi Rajabi, Giulio Vistoli, Enzo Santaniello. New synthesis of 6{3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid and evaluation of the influence of adamantyl group on the DNA binding of a naphthoic retinoid. Bioorganic Chemistry. 39, 2011, 151–158.
  8. Mohammad Ali Khalilzadeh, Zinattosadat Hossaini, Faramarz Rostami Charati, Sara Hallajian, Mehdi Rajabi. A mild and efficient method for the synthesis of a new class of furo{3,2-c]chromenes in aqueous media. Molecular Diversity. 15, 2011, 445-50.
  9. Mehdi Rajabi, Jamshid Mehrzad, Elena Gorincioi, Enzo Santaniello. Antiproliferative activity of N6-Isopentenyladenosine (iPA) on HCT-15 colon carcinoma cell line. Nucleic Acid Therapeutics. 21, 2011, 355-358.
  10. Fatemeh Tavakolinia, Tayebeh Baghipour, Zinatossadat Hossaini, Daryoush Zareyee, Mohammad A. Khalilzadeh, Mehdi Rajabi. Antiproliferative activity of novel thiopyran analogues against cancer cell lines. Nucleic Acid Therapeutics. 22, 2012, 265-270.
  11. Mehdi Rajabi, Elena Gorincioi, Enzo Santaniello. Antiproliferative activity of Kinetin Riboside on HCT-15 colon cancer cell line. Nucleosides, Nucleotides, and Nucleic Acids. 31(6), 2012, 474-481.
  12. Mehdi Rajabi, Mohammad Ali Khalilzadeh, Fatemeh Tavakolinia, Paola Signorelli, Riccardo Ghidoni, Enzo Santaniello. Naphthalene-fused (α-alkoxycarbonyl)methylene-γ-butyrolactones: antiproliferative activity and binding to bovine serum albumin and DNA. DNA and Cell Biology. 31(5), 2012, 783-789.
  13. Masoumeh Hosseinzadeh, Hamid A. Hadi, Jamaludin Mohamad, Mohammad A. Khalilzadeh, Mohammad Reza Zardoost, Mehdi Rajabi. Isolation and characterization of bioactive compounds from the bark of Litsea costalis. Journal of Photochemistry and Photobiology B: Biology. 128, 2013, 85–9.
  14. Roberta Di Benedetto, Luca Zanetti, Monica Varese, Mehdi Rajabi, Riccardo Di Brisco, Luigi Panza. Protected sphingosine from phytosphingosine as efficient acceptor in glycosylation reaction. Organic Letters. 7;16(3), 2014, 952-955.
  15. Yi Shu, Fengmei Pi, Ashwani Sharma, Mehdi Rajabi, Farzin Haque, Dan Shu, Markos Leggas, B. Mark Evers, Peixuan Guo. Stable RNA nanoparticles as potential new generation drugs for cancer therapy. Advanced Drug Delivery Reviews. 66, 2014, 74-89.
  16. Mehdi Rajabi, Moreno Lanfranchi, Federica Campo, Luigi Panza. Synthesis of a series of hydroxycarboxylic acids as standards for oxidation of nonanoic acid. Synthetic Communications, 44, 2014, 1149-1154.
Research and Conference Presentations
  • 2014 Markey Cancer Center Research Day, University of Kentucky, Lexington, KY, USA, May 22, 2014.
  • 2013 Rustbelt RNA Meeting RRM, Cleveland, OH, USA, September 18-19, 2013.
  • 4th Postgraduate Symposium in Chemical Biology, Department of Chemistry, Cambridge, UK, 2010.
  • Hot Topics in Oncology, University of Milan, San Paolo Hospital, December 1, 2010. Milan, Italy.
  • The 2nd National Conference of Medicinal Chemistry, University of Coimbra, November 28-30, 2010, Coimbra, Portugal.
  • Innovation in High-definition Imaging, Tools for Small Animal Research, University of Milan, Department of Pharmacological Sciences, November 9, 2010, Milan, Italy.
  • The 5th Summer School of Medicinal Chemistry at the University of Regensburg, September 13-15, 2010, Regensburg, Germany.
  • Challenges in Organic Chemistry and Chemical Biology (ISACS) July 1-9, 2010, San Francisco, California.
  • The 29th European School of Medicinal Chemistry (ESMEC) and “E. Duranti” National Seminar for PhD Students, September 13-18, 2009, Universita’ degli studi di Urbino, Italy.
  • The 14th Summer School on Pharmaceutical Analysis (SSPA), September 7-9, 2009 Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Università degli Studi di Milano, Italy.
  • The 4th Annual National Conference, Italian Proteomics Association, June 22-25, 2009, Universita’ degli studi di Milano-Bicocca, Italy.
  • The 1st Biology Conference for Iranian Scholars in Europe, December 6-7, 2008, Hamburg, Germany.
  • The 5th Annual Meeting of European Network of Doctoral Studies in Pharmaceutical Sciences, Universita’ degli studi di Milano, November 17-19, 2008, Milan, Italy.
  • The 1st Symposium of Phytochemistry and Natural Products, Azad University of Ghaemshahr, April 23-24, 2008, Iran.
  • The 1st Iranian Congress of Phytochemistry Tehran, Medicinal Plants and Drugs Institute, Shahid Beheshti University, December 11-13, 2007, Tehran, Iran.
  • The 9th Iranian Congress of Biochemistry & the 2th International Congress of Biochemistry and Molecular Biology Shiraz-Iran, Oct 29–Nov 1, 2007, Shiraz, Iran.
  • The 3rd Iranian Congress of Medical Plant, October 23-24, 2007 Tehran, Iran.
  • The 3rd Iranian Conference of Novel Drug Delivery System, Medical Science of Tehran University, June 20-21, 2007 Tehran, Iran.
  • The 13th Iranian Seminar of Organic chemistry, Bu-Ali Sina University, September 7-9, 2006, Hamedan, Iran.
  • The 7th Iranian Conference of Biophysical Chemistry, Research Institute for Fundamental Science of Tabriz University July18-19, 2006, Tabriz, Iran.
  • The 12th Iranian Seminar of Organic Chemistry, March 7-9, 2006, Jundi Shapour University of Medical Sciences.
Invited Lectures
  • Department of Hematology, Oncology and Blood and Marrow Transplantation, The University of Iowa. Bioconjugation of small bioactive molecules to nanoparticles via cleavable linkers. June 24, 2014. Iowa City, Iowa, USA.
  • National Institute of Chemistry, Synthesis of heterocycle-based analogs of resveratrol and their antitumor properties. April 2th 2012. Ljubljana, Slovenia.
Previous Positions or Appointments
  • Postdoctoral Fellow in RNA Nanotechnology for cancer therapy, Nanobiotechnology Center, Markey Cancer Center, and Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY (2013 – 2014)
  • Postdoctoral in PET Radiochemistry/ Cancer Imaging Diagnosis, Department of PET-Nuclear Medicine, Università degli Studi di Milano-Bicocca, San Gerardo Hospital, Monza-Milano, Italy (2012 – 2013)
  • Postdoc in Organic/ Medicinal Chemistry, Università del Piemonte Orientale A. Avogadro, Novara, Italy (2011 – 2012)

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