Staff

Dhruba J. Bharali, Ph.D.

EDUCATION

  • University of Delhi, Delhi, India Ph.D. 2003, Chemistry (Nanotechnology /Drug Delivery)
  • University of Delhi, Delhi, India M. Phil. 2000, Chemistry
  • University of Delhi, Delhi, India M.Sc. 1999, Chemistry

RESEARCH INTERESTS

  • Biodegradable/biocompatible nanoparticles for biomedical applications
  • Nanoparticles-mediated targeted delivery and therapy
  • Nanomaterials-based advanced imaging modalities (MRI, fluorescence imaging)
  • Nanoparticles-mediated gene delivery
  • Nanotechnology-based vaccine formulation
Selected Publications
  1. T. Sudha, D. J. Bharali, M. Yalcin, N. H. Darwish, M. D. Coskun, K. A. Keating, H. Y. Lin, P. J. Davis, S. A. Mousa, Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac, Nanomedicine (London), 2017, 12:195-205.
  2. D. J. Bharali, T. Sudha, H. Cui, B. M. Mian, S. A. Mousa, Anti-CD24 nano-targeted delivery of docetaxel for the treatment of prostate cancer, Nanomedicine, 2017, 13:263-273.
  3. A. B. Shirode, D. J. Bharali, S. Nallanthighal, J. K. Coon, S. A. Mousa, R. Reliene, Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention, International Journal of Nanomedicine, 2015, 10:475-484.
  4. A. M. Safer, N. A. Hanafy, D. J. Bharali, H. Cui, S. A. Mousa, Effect of green tea extract encapsulated into chitosan nanoparticles on hepatic fibrosis collagen fibers assessed by atomic force microscopy in rat hepatic fibrosis model, Journal of Nanoscience and Nanotechnology, 2015, 15:6452-6459.
  5. W. Hariri, T. Sudha, D. J. Bharali, H. Cui, S. A. Mousa, Nano-targeted delivery of toremifene, an estrogen receptor-alpha blocker in prostate cancer, Pharmaceutical Research, 2015, 32:2764-2774.
  6. I. A. Siddiqui, D. J. Bharali, M. Nihal, V. M. Adhami, N. Khan, J. C. Chamcheu, M. I. Khan, S. Shabana, S. A. Mousa, H. Mukhtar, Excellent anti-proliferative and pro-apoptotic effects of (-)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo, Nanomedicine, 2014, 10:1619-1626.
  7. N. Khan, D. J. Bharali, V. M. Adhami, I. A. Siddiqui, H. Cui, S. M. Shabana, S. A. Mousa, H. Mukhtar, Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol egcg effectively inhibits prostate cancer cell growth in a xenograft model, Carcinogenesis, 2014, 35:415-423.
  8. A. A. Lugade, D. J. Bharali, V. Pradhan, G. Elkin, S. A. Mousa, Y. Thanavala, Single low-dose un-adjuvanted HBsAg nanoparticle vaccine elicits robust, durable immunity, Nanomedicine, 2013, 9:923-934.
  9. D. J. Bharali, M. Yalcin, P. J. Davis, S. A. Mousa, Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: A nanomedicine approach to treat drug-resistant breast cancer, Nanomedicine (London), 2013, 8:1943-1954.
  10. D. J. Bharali, D. Armstrong, S. A. Mousa, Hybrid polymeric nanoparticles: Potential candidate for ophthalmic delivery, Methods in Molecular Biology, 2013, 1028:279-286.
  11. M. Yalcin, H. Y. Lin, T. Sudha, D. J. Bharali, R. Meng, H. Y. Tang, F. B. Davis, S. C. Stain, P. J. Davis, S. A. Mousa, Response of human pancreatic cancer cell xenografts to tetraiodothyroacetic acid nanoparticles, Hormones and Cancer, 2013, 4:176-185.
  12. D. J. Bharali, S. A. Mousa, Relevance of nanotechnology in modulating oxidative stress: An overview, Methods in Molecular Biology, 2013, 1028:289-292.
  13. S. A. Mousa, M. Yalcin, D. J. Bharali, R. Meng, H. Y. Tang, H. Y. Lin, F. B. Davis, P. J. Davis, Tetraiodothyroacetic acid and its nanoformulation inhibit thyroid hormone stimulation of non-small cell lung cancer cells in vitro and its growth in xenografts, Lung Cancer, 2012, 76:39-45.
  14. M. S. Jayaraman, D. J. Bharali, T. Sudha, S. A. Mousa, Nano chitosan peptide as a potential therapeutic carrier for retinal delivery to treat age-related macular degeneration, Molecular Vision, 2012, 18:2300-2308.
  15. S. A. Mousa, D. J. Bharali, Nanotechnology-based detection and targeted therapy in cancer: Nano-bio paradigms and applications, Cancers (Basel), 2011, 3:2888-2903.
  16. D. J. Bharali, I. A. Siddiqui, V. M. Adhami, J. C. Chamcheu, A. M. Aldahmash, H. Mukhtar, S. A. Mousa, Nanoparticle delivery of natural products in the prevention and treatment of cancers: Current status and future prospects, Cancers (Basel), 2011, 3:4024-4045.
  17. M. Yalcin, E. Dyskin, L. Lansing, D. J. Bharali, S. S. Mousa, A. Bridoux, A. H. Hercbergs, H. Y. Lin, F. B. Davis, G. V. Glinsky, A. Glinskii, J. Ma, P. J. Davis, S. A. Mousa, Tetraiodothyroacetic acid (tetrac) and nanoparticulate tetrac arrest growth of medullary carcinoma of the thyroid, Journal of Clinical Endocrinology and Metabolism, 2010, 95:1972-1980.
  18. M. Yalcin, D. J. Bharali, E. Dyskin, E. Dier, L. Lansing, S. S. Mousa, F. B. Davis, P. J. Davis, S. A. Mousa, Tetraiodothyroacetic acid and tetraiodothyroacetic acid nanoparticle effectively inhibit the growth of human follicular thyroid cell carcinoma, Thyroid, 2010, 20:281-286.
  19. D. J. Bharali, S. A. Mousa, Emerging nanomedicines for early cancer detection and improved treatment: Current perspective and future promise, Pharmacology & Therapeutics, 2010, 128:324-335.
  20. M. Yalcin, D. J. Bharali, L. Lansing, E. Dyskin, S. S. Mousa, A. Hercbergs, F. B. Davis, P. J. Davis, S. A. Mousa, Tetraiodothyroacetic acid (tetrac) and tetrac nanoparticles inhibit growth of human renal cell carcinoma xenografts, Anticancer Research, 2009, 29:3825-3831.
  21. I. A. Siddiqui, V. M. Adhami, D. J. Bharali, B. B. Hafeez, M. Asim, S. I. Khwaja, N. Ahmad, H. Cui, S. A. Mousa, H. Mukhtar, Introducing nanochemoprevention as a novel approach for cancer control: Proof of principle with green tea polyphenol epigallocatechin-3-gallate, Cancer Research, 2009, 69:1712-1716.
  22. D. J. Bharali, M. Khalil, M. Gurbuz, T. M. Simone, S. A. Mousa, Nanoparticles and cancer therapy: A concise review with emphasis on dendrimers, International Journal of Nanomedicine, 2009, 4:1-7.
  23. J. LaRocque, D. J. Bharali, S. A. Mousa, Cancer detection and treatment: The role of nanomedicines, Molecular Biotechnology, 2009, 42:358-366.
  24. D. J. Bharali, U. Dier, P. J. Davis, S. A. Mousa, Tetrac-conjugated quantum dots for diagnosis and treatment of pancreatic cancer: An in vitro evaluation, Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry, 2009, 9:219-223.
  25. D. J. Bharali, V. Pradhan, G. Elkin, W. Qi, A. Hutson, S. A. Mousa, Y. Thanavala, Novel nanoparticles for the delivery of recombinant hepatitis B vaccine, Nanomedicine, 2008, 4:311-317.
  26. W. E. Bawarski, E. Chidlowsky, D. J. Bharali, S. A. Mousa, Emerging nanopharmaceuticals, Nanomedicine, 2008, 4:273-282.
  27. S. A. Mousa, D. J. Bharali, D. Armstrong, From nutraceuticals to pharmaceuticals to nanopharmaceuticals: A case study in angiogenesis modulation during oxidative stress, Molecular Biotechnology, 2007, 37:72-80.
  28. I. Roy, T. Y. Ohulchanskyy, D. J. Bharali, H. E. Pudavar, R. A. Mistretta, N. Kaur, P. N. Prasad, Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery, Proceedings of the National Academy of Sciences of the United States of America, 2005, 102:279-284.
  29. D. J. Bharali, D. W. Lucey, H. Jayakumar, H. E. Pudavar, P. N. Prasad, Folate-receptor-mediated delivery of inp quantum dots for bioimaging using confocal and two-photon microscopy, Journal of the American Chemical Society, 2005, 127:11364-11371.
  30. D. J. Bharali, I. Klejbor, E. K. Stachowiak, P. Dutta, I. Roy, N. Kaur, E. J. Bergey, P. N. Prasad, M. K. Stachowiak, Organically modified silica nanoparticles: A nonviral vector for in vivo gene delivery and expression in the brain, Proceedings of the National Academy of Sciences of the United States of America, 2005, 102:11539-11544.
  31. I. Klejbor, E. K. Stachowiak, D. J. Bharali, I. Roy, I. Spodnik, J. Morys, E. J. Bergey, P. N. Prasad, M. K. Stachowiak, ORMOSIL nanoparticles as a non-viral gene delivery vector for modeling polyglutamine induced brain pathology, Journal of Neuroscience Methods, 2007, 165:230-243.
  32. D. J. Bharali, S. A. Mousa, Y. Thanavala, Micro- and nanoparticle-based vaccines for hepatitis B, Advances in Experimental Medicine and Biology, 2007, 601:415-421.
  33. S. Kim, Q. Zheng, G. S. He, D. J. Bharali, H. E. Pudavar, A. Baev, P. N. Prasad, Aggregation-enhanced fluorescence and two-photon absorption in nanoaggregates of a 9,10-bis{4 ‘-(4 ”-aminostyryl)styryl}anthracene derivative, Advanced Functional Materials, 2006, 16:2317-2323.
  34. D. J. Bharali, S. K. Sahoo, S. Mozumdar, A. Maitra, Cross-linked polyvinylpyrrolidone nanoparticles: A potential carrier for hydrophilic drugs, Journal of Colloid and Interface Science, 2003, 258:415-423.
Books/Book Chapters
  1. Oxidative Stress and Nanotechnology: Methods and Protocols. Edited by D. Armstrong, D. J. Bharali; Publisher: Humana Press, 2013.
  2. Hung-Yun Lin, Faith B. Davis, Mary K. Luidens, Aleck Hercbergs Shaker A. Mousa, Dhruba J. Bharali and Paul J. Davis. Newly-Recognized Small Molecule Receptors on Human Breast Cancer Cell Integrin αvβ3 that Affect Tumor Cell Behavior, In: Targeting New Pathways and Cell Death in Breast Cancer. Edited by  L. Aft; Publisher: InTech, 2012, pp 85-96.
  3. Dhruba J Bharali,Shaker A Mousa, Yasmin Thanavala. Micro- and Nanoparticle-based Vaccines for Hepatitis B, In: Immune-Mediated Diseases: From Theory to Therapy. Edited by M. R. Shurin and Y. S. Smolkin; Publisher: Springer, 2007, pp 415-21.
  4. Susmita Mitra, Dhruba Jyoti Bharali, Amarnath Maitra, Hydrogel Nanoparticles synthesized of Cross-Linked PolyvinylpyrrolidoneIn: Dekker Encyclopedia of Nanoscience and Nanotechnology. Edited by J. A. Schwarz, S. E. Lyshevski, K. Putyera, C. I. Contescu; Publisher: Marcel Dekker Inc., 2004, pp. 1403- 1414.
Selected Research and Conference Presentations
    • Dhruba J. BharaliNanotechnology and Cancer Imaging & Treatment, The 2011 Annual Meeting of the AAPS Northeast Regional Discussion Group (NERDG) , April 15, 2011, Rocky Hill, CT, USA
    • Dhruba J. Bharali, Usawadee Dier, Tessa M Simone, Shaker A Mousa. Biodegradable Nanoparticles Encapsulating Paclitaxel: A Potential Platform for Site-specific Therapy and Imaging of Ovarian Cancer, Pharmaceutical Sciences World Congress 2010, 14-18 November 2010,  New Orleans, Louisiana, USA
    • Shaker A. Mousa, Dhruba J. Bharali, Lubor Borsig, Emmy Dier, Shaymaa S. Mousa, Murat Yalcin, and Patricia Phillips. Site-directed Therapy with Non-anticoagulant Heparins and Chemotherapy in Breast Cancer. 5th Era of Hope Meeting (Department of Defense Program), June 25-28, 2008, Baltimore, Maryland, USA
    • Dhruba J. Bharali, Dalia Chattopadhyay, Subho Mozumdar, Amarnath Maitra. Cross-Linked Polyvinylpyrrolidone Nanoparticles as Non-Viral Vectors for In Vitro and In Vivo Delivery of Genes. Proceedings of the 30th Annual Meeting and Exposition of the Controlled Release Society; July 19–23 2003; 579, Glasgow, Scotland, U.K.
Patents
  1. Amarnath Maitra, Subho Mozumdar, Susmita Mitra and Dhruba Jyoti Bharali; A Process for the preparation Of pH sensitive, mucoadhesive smart hydrogel nanoparticles as potential carriers for systemic delivery of water soluble drugs through oral route, Indian Patent No. 217609
  2. Paras N. Prasad, Michal K. Stachowiak, Earl J. Bergey, Purnendu Dutta, Dhruba J. Bharali, Ilona Klejbor, Tymish Ohulchanskyy , Indrajit Roy, Amino Functionalized ORMOSIL Nanoparticles as delivery vehicles, USA Patent application No. 20060088599 A1, (2006)
  3. Paras N. Prasad, Richard Mazurchuk, Dhruba J. Bharali, Dinesh K. Sukumaran, Earl J Bergey, Joseph Spernyak, Mukund Seshadri, Hybird Inorganic Nanoparticles, Methods of Using and Methods of Making. USA Patent application No 20060222587 A1, (2006)
Awards
  • Junior Research Fellow (New Millennium Initiative in Technology and Leadership in India NMITLI) sponsored by Council of Scientific and Industrial Research (CSIR), Government of India, 2001-2003
Previous Positions or Appointments
  • Senior Nanotechnology Scientist, PRI, Albany College of Pharmacy and Health Sciences, Rensselaer, NY (06/07 – 03/09)
  • Postdoctoral Fellow, Dept. of Immunology, Roswell Park Cancer Institute, Buffalo, NY (12/05 – 05/07)
  • Postdoctoral Associate, Institute for Laser Photonics and Biophotonics, SUNY at Buffalo, Buffalo, NY (09/03 – 12/05)

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