Staff

Kelly A. Keating, Ph.D.

EDUCATION

  • Ph.D. Chemistry, University of California-Davis
  • B.S. Chemistry, University of Wisconsin-Madison

RESEARCH INTERESTS

  • Scientific editing and writing, chemistry, small drug molecules, drug discovery, NMR spectroscopy, analytical instrumentation, laboratory management
Selected Publications
  1. PJ Davis, HY Lin, AA Hercbergs, KA Keating, SA Mousa, How thyroid hormone works depends upon cell type, receptor type, and hormone analogue: Implications in cancer growthDiscov Med, 2019, 27:111-117.
  2. PJ Davis, HY Tang, A Hercbergs, HY Lin, KA Keating, SA Mousa, Bioactivity of thyroid hormone analogs at cancer cells, Front Endocrinol (Lausanne), 2018, 9:739.
  3. H-Y Lin, Y-T Chin, Y-J Shih, Y-R Chen, M Leinung, KA Keating, SA Mousa, PJ Davis, In tumor cells, thyroid hormone analogues non-immunologically regulate PD-L1 and PD-1 accumulation that is anti-apoptotic, Oncotarget, 2018, 9:34033-34037.
  4. SA Mousa, GV Glinsky, H-Y Lin, O Ashur-Fabian, A Hercbergs, KA Keating, PJ Davis, Contributions of thyroid hormone to cancer metastasis, Biomedicines, 2018, 6(3):89.
  5. T Sudha, DJ Bharali, M Yalcin, NH Darwish, M Debreli Coskun, KA Keating, HY Lin, PJ Davis, SA Mousa, Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac, Int J Nanomedicine, 2017, 12:1305-1315.
  6. T Sudha, DJ Bharali, M Yalcin, NH Darwish, MD Coskun, KA Keating, HY Lin, PJ Davis, SA Mousa, Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac, Nanomedicine (Lond), 2017, 12:195-205.
  7. KA Keating, Tracking health policy reform (2012 AMWA Annual Conference Coverage), in:  AMWA Journal, 2012, pp. e1-e2.
  8. KA Keating, Falsifications and retractions (2012 AMWA Annual Conference Coverage), in:  AMWA Journal, 2012.
  9. KA Keating, Your paper is rejected, now what? (2011 AMWA Annual Conference Coverage), in:  AMWA Journal, 2011, pp. e9-e10.
  10. L Hu, HM Martin, O Arce-Bulted, MN Sugihara, KA Keating, TI Strathmann, Oxidation of carbamazepine by Mn(VII) and Fe(VI): Reaction kinetics and mechanism, Environ Sci Technol, 2009, 43:509-515.
  11. KA Keating, O McConnell, Y Zhang, L Shen, W Demaio, L Mallis, S Elmarakby, A Chandrasekaran, NMR characterization of an S-linked glucuronide metabolite of the potent, novel, nonsteroidal progesterone agonist tanaproget, Drug Metab Dispos, 2006, 34:1283-1287.
  12. LG Marzilli, JS Saad, Z Kuklenyik, KA Keating, Y Xu, Relationship of solution and protein-bound structures of DNA duplexes with the major intrastrand cross-link lesions formed on cisplatin binding to DNA, J Am Chem Soc, 2001, 123:2764-2770.
  13. KA Keating, JD Myers, JG Pelton, RA Bair, DE Wemmer, PD Ellis, Development and use of a virtual NMR facility, J Magn Reson, 2000, 143:172-183.
  14. A Schur, KA Keating, DA Payne, T Valdez, KR Yates, JD Myers, Collaborative suites for experiment-oriented scientific research, Interactions, 1998, 5:40-47.
  15. KA Keating, GN La Mar, FY Shiau, KM Smith, 1H NMR study of the molecular and electronic structure of paramagnetic iron chlorin complexes of myoglobin: Dynamic heterogeneity of the heme pocket, J Am Chem Soc, 1992, 114:6513-6520.
  16. L Banci, LB Dugad, GN La Mar, KA Keating, C Luchinat, R Pierattelli, 1H Nuclear magnetic resonance investigation of cobalt(II) substituted carbonic anhydrase, Biophys J, 1992, 63:530-543.
  17. KA Keating, JS De Ropp, GN La Mar, AL Balch, FY Shiau, KM Smith, Assignment by 2D NMR bond correlation spectroscopy of hyperfine-shifted and strongly relaxed protons in iron porphyrin and chlorin complexes, Inorg Chem, 1991, 30:3258-3263.
  18. BK Teo, K Keating, YH Kao, Observation of plasmon frequency in the optical spectrum of Au18Ag20 cluster: The beginning of the collective phenomenon characteristics of the bulk?,
    J Am Chem Soc, 1987, 109:3494-3495.
  19. GK Wertheim, J Kwo, BK Teo, KA Keating, XPS study of bonding in ligated Au clusters,
    Solid State Commun, 1985, 55:357-361.
  20. BK Teo, K Keating, Novel triicosahedral structure of the largest metal alloy cluster: Hexachlorododecakis(triphenylphosphine)-gold-silver cluster {(Ph3P)12Au13Ag12Cl6}m+, J Am Chem Soc, 1984, 106:2224-2226.
Patents
  1. Shen L, Keating K, McConnell O, DeMaio W, Chandrasekaran A, inventors; Wyeth, assignee. Tanaproget derivatives, metabolites, and uses thereof. US patent 7,569,679. August 4, 2009.
Awards
  • Wyeth Chemical and Screening Sciences Above and Beyond Award, 2004
  • AT&T Bell Laboratories Exceptional Contribution Award, 1985
Professional Organizations
  • American Chemical Society
  • American Medical Writers Association
Previous Positions or Appointments
  • Senior Research Specialist (Interim Director), Roy J. Carver Metabolomics Center, University of Illinois Urbana-Champaign
  • Senior Research Scientist II, Wyeth, Collegeville, PA, Manager of NMR labs and spectroscopy services (IR, CHN) for 65 chemists
  • Visiting NMR Scientist and Senior Research Scientist, Pacific Northwest National Laboratory (PNNL), Richland, WA
  • Postdoctoral Research Associate and Graduate Lecturer, Emory University, Atlanta, GA
  • Senior Support Scientist, Biosym Technologies, Inc. (now Accelyrs), San Diego, CA
  • Senior Technical Associate, AT&T Bell Laboratories, Murray Hill, NJ

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