Staff

Bruce Hay, Ph.D.

EDUCATION

  • Ph.D., Organic Chemistry, University of Minnesota
  • Sc.B., Chemistry, Brown University

RESEARCH INTERESTS

  • Medicinal Chemistry
  • Process Chemistry
  • Imaging agents
Selected Publications
  1. BA Hay, BC Bales, PJ Bonitatibus, RE Colborn, EA Pressman, PA Buckley, P Bui, JL Lee, DE Meyer, Discovery and development of GEH121333, a superparamagnetic iron oxide nanoparticle contrast agent for magnetic resonance imaging of angiogenesis and inflammation, Contrast Media Mol Imaging, in preparation.
  2. JW Hicks, O Sadovski, J Parkes, S Houle, BA Hay, RL Carter, AA Wilson, N Vasdev, Radiosynthesis and ex vivo evaluation of {(18)F}-(S)-3-(6-(3-fluoropropoxy)benzo{d}isoxazol-3-yl)-5-(methoxymethyl)oxazoli din-2-one for imaging MAO-B with PET, Bioorg Med Chem Lett, 2015, 25:288-291.
  3. JL Hawkins, MD Robbins, LC Warren, D Xia, SF Petras, JJ Valentine, AH Varghese, IK Wang, TA Subashi, LD Shelly, BA Hay, KT Landschulz, KF Geoghegan, HJ Harwood, Jr., Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals, J Pharmacol Exp Ther, 2008, 326:801-808.
  4. BA Hay, B Abrams, AY Zumbrunn, JJ Valentine, LC Warren, SF Petras, LD Shelly, A Xia, AH Varghese, JL Hawkins, JA Van Camp, MD Robbins, K Landschulz, HJ Harwood, Jr., Aminopyrrolidineamide inhibitors of site-1 protease, Bioorg Med Chem Lett, 2007, 17:4411-4414.
  5. BA Hay, BM Cole, FM DiCapua, GW Kirk, MC Murray, RA Nardone, DJ Pelletier, AP Ricketts, AS Robertson, TW Siegel, Small molecule somatostatin receptor subtype-2 antagonists, Bioorg Med Chem Lett, 2001, 11:2731-2734.
  6. BA Hay, JW Homiski, MA Priest, A simplified method for synthesis of tetrahydroisoalpha acid standards for high-performance liquid chromatography, J. Am. Soc. Brew. Chem., 1994, 49:115-118.
  7. BA Hay, JW Homiski, JL Howie, Differences in ultraviolet absorbance of tetrahydroiso-alpha-acid components, J. Am. Soc. Brew. Chem., 1994, 52:54-56.
  8. RS Glass, WP Singh, BA Hay, Oxidation of sulfides to sulfoxides with titanium(III) chloride and hydrogen peroxide, Sulfur Lett, 1994, 17:281-286.
  9. RS Glass, W Pal Singh, BA Hay, Diastereoselective oxidation of substituted thietanes and stereoselective oxidation of their sulfoxides, Tetrahedron Lett, 1994, 35:5809-5812.
  10. BA Hay, JW Homiski,  Efficient one-step preparation of the beer additive tetrahydroiso-alpha acids, J Agric Food Chem, 1991, 39:1732-1734.
  11. PG Gassman, BA Hay, Mechanistic insight into the photoinduced rearrangement of the tricyclo{4.1.0.02,7}heptyl skeleton, J Am Chem Soc, 1986, 108:4227-4228.
  12. PG Gassman, BA Hay, Alkyl group migration in photoinduced cation radical reactions, J Am Chem Soc, 1985, 107:4075-4076.
Patents
  1. Hay, B.A.; Grimmond, B.J.; Lowery,L.A.; Li,Q.; Spooner, P.M.; Morton, C.A. Method of formalin based tissue fixation. US0.
  2. Hay, B.A.; Webster, J. M. Labelled molecular imaging agents and methods of use. US3.
  3. Graziani, D.M.; Foo, T.K-F.; Marinelli, L.; Meyer, D.E.; Hay, B.A. Systems and methods for magnetic material imaging. US712.
  4. Butts, M.D.; Colborn, R.E.; Bonitatibus,P.J.; Torres, A.S.; Bales, B.C.; Marino, M.E.; Hay, B.A.; Kulkarni, A.M. Nanoparticle contrast agents comprising oxides and silane functionalized zwitterions. US7.
  5. Bales, B.C.; Grimmond, B.J.; Meyer, D.E.; Hay, B.A. Heat stable nanoparticles coated with PEG phosphonate derivatives. US7.
  6. Hay, B.A.; Meyer, D.E.; Bales, B.C.; Luttrell, M.T. Superparamagnetic nanoparticles with PEG substituted α-hydroxyphosphonate shells. US3.
  7. Hay, B.A.; Bales, B.C.; Luttrell, M.T.; Kandapallil, B.I.I. Nanoparticulate metal oxide compositions using a phosphorylated polyol. US1.
  8. Hay, B.A.; Bales, B.C.; Luttrell, M.T.; Kandapallil, B.I.I. Nanoparticulate metal oxide compositions using a phosphorylated polyol. US2.
  9. Bales, B.C.; Hay, B.A.; Kandapallil, B.I.I. Preparation of hydrophilic α-hydroxyphosphonic acid conjugates for treating water insoluble nanoparticles as contrast agents. US2.
  10. Bonitatibus,P.J.; Butts, M.D.; Colborn, R.E.; Kulkarni, A.M.; Hay, B.A.; Torres, A.S.; Bales, B.C.; Marino, M.E.; Nanoparticle contrast agents for diagnostic imaging. US4.
  11. Bonitatibus,P.J.; Butts, M.D.; Colborn, R.E.; Kulkarni, A.M.; Hay, B.A.; Torres, A.S.; Bales, B.C.; Marino, M.E.; Nanoparticle contrast agents for diagnostic imaging. US8.
  12. Bonitatibus,P.J.; Butts, M.D.; Colborn, R.E.; Kulkarni, A.M.; Hay, B.A.; Torres, A.S.; Bales, B.C.; Marino, M.E.; Nanoparticle contrast agents for diagnostic imaging. US9.
  13. Butts, M.D.; Colborn, R.E.; Bonitatibus,P.J.; Kulkarni, A.M.; Hay, B.A.;Torres, A.S.; Bales, B.C.; Marino, M.E. Nanoparticle contrast agents for diagnostic imaging. US4.
  14. Lefker, B.A.; Brodney, M.A.; Sakya, S.M.; Hay, B.A.; Wessel, M.D.; Conn, E.L. Preparation of N-alkylaminomethylpyridinylpyrimidinone and N-alkylaminomethylbipyrimidinylone derivatives and their use as GSK-3 inhibitors. WO.
  15. Hay, B.A.; Cole, B.M.; Ricketts, A.P. Preparation of amino acid derivatives as somatostatin antagonists and agonists that act at the sst subtype 2 receptor. US.
  16. Cole, B.M.; Ricketts, A.P.; Hay, B.A. Preparation of amino acid derivatives as somatostatin antagonists and agonists. US.
  17. Hay, B.A.; Ricketts, A.P.; Cole, B.M. Preparation of N-
Awards
  • Pfizer Central Research Achievement Award, 1992
Previous Positions or Appointments
  • Senior Chemist, General Electric Global Research Center, Niskayuna NY
  • Associate Research Fellow, Pfizer Global Research, Groton CT

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